Publication: Biological and biocompatible characteristics of fullerenols nanomaterials for tissue engineering
Authors
Zhao, Yizhe ; Shen, Xinyuan ; Ma, Ruimeng ; Hou, Yiting ; Qian, Yun ; Fan, Cunyi
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-316
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info:eu-repo/semantics/article
Description
Abstract
. Fullerenes, as hydrophobic molecules, are
limited in biomedical function due to their very low
solubility. But taking C60(OH)x as an example, the
properties of fullerenols were analyzed. It was found that
fullerenols had good stability, water solubility, good
biocompatibility and low cytotoxicity by adding a
hydroxyl group to carbon atoms. In the biomedical field,
it has been found that fullerene C60 can be used as a
powerful free radical scavenger, with antioxidant
activity, with antibacterial and inhibitory effects on
cancer cells. Fullerenols inherit the good properties of
fullerenes, and are better used in cancer treatment,
including loading drug therapy and directly as an
anticancer drug. In addition, fullerenols are also used in
the repair of myocardial injury, the treatment of
myocardial infarction and neuroprotection. With the
development of tissue engineering technology, the
preparation of nerve scaffolds which can improve
ischemia, hypoxia and oxidative stress after nerve injury
has become a research hotspot. The electron absorption
and reduction characteristics of fullerenols in biomedical
research bring new ideas for the treatment of oxidative
stress in the repair of peripheral nerve defects. It seems
that the research on fullerenols loaded neural scaffold
has great prospects.
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Citation
Histology and Histopathology Vol. 36, nº7 (2021)
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