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Biological and biocompatible characteristics of fullerenols nanomaterials for tissue engineering

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dc.contributor.authorZhao, Yizhe
dc.contributor.authorShen, Xinyuan
dc.contributor.authorMa, Ruimeng
dc.contributor.authorHou, Yiting
dc.contributor.authorQian, Yun
dc.contributor.authorFan, Cunyi
dc.date.accessioned2023-01-19T09:30:34Z
dc.date.available2023-01-19T09:30:34Z
dc.date.issued2021
dc.description.abstract. Fullerenes, as hydrophobic molecules, are limited in biomedical function due to their very low solubility. But taking C60(OH)x as an example, the properties of fullerenols were analyzed. It was found that fullerenols had good stability, water solubility, good biocompatibility and low cytotoxicity by adding a hydroxyl group to carbon atoms. In the biomedical field, it has been found that fullerene C60 can be used as a powerful free radical scavenger, with antioxidant activity, with antibacterial and inhibitory effects on cancer cells. Fullerenols inherit the good properties of fullerenes, and are better used in cancer treatment, including loading drug therapy and directly as an anticancer drug. In addition, fullerenols are also used in the repair of myocardial injury, the treatment of myocardial infarction and neuroprotection. With the development of tissue engineering technology, the preparation of nerve scaffolds which can improve ischemia, hypoxia and oxidative stress after nerve injury has become a research hotspot. The electron absorption and reduction characteristics of fullerenols in biomedical research bring new ideas for the treatment of oxidative stress in the repair of peripheral nerve defects. It seems that the research on fullerenols loaded neural scaffold has great prospects.es
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dc.format.extent7es
dc.identifier.citationHistology and Histopathology Vol. 36, nº7 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-316
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/127544
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFullerene derivativeses
dc.subjectFullerenolses
dc.subjectBiomedicinees
dc.subjectNeural scaffoldes
dc.subjectOxidative stresses
dc.subjectNerve regenerationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleBiological and biocompatible characteristics of fullerenols nanomaterials for tissue engineeringes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36, nº7 (2021)