Browsing by Subject "Biomedicine"

Now showing 1 - 3 of 3
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    Biological and biocompatible characteristics of fullerenols nanomaterials for tissue engineering
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2021) Zhao, Yizhe; Shen, Xinyuan; Ma, Ruimeng; Hou, Yiting; Qian, Yun; Fan, Cunyi
    . Fullerenes, as hydrophobic molecules, are limited in biomedical function due to their very low solubility. But taking C60(OH)x as an example, the properties of fullerenols were analyzed. It was found that fullerenols had good stability, water solubility, good biocompatibility and low cytotoxicity by adding a hydroxyl group to carbon atoms. In the biomedical field, it has been found that fullerene C60 can be used as a powerful free radical scavenger, with antioxidant activity, with antibacterial and inhibitory effects on cancer cells. Fullerenols inherit the good properties of fullerenes, and are better used in cancer treatment, including loading drug therapy and directly as an anticancer drug. In addition, fullerenols are also used in the repair of myocardial injury, the treatment of myocardial infarction and neuroprotection. With the development of tissue engineering technology, the preparation of nerve scaffolds which can improve ischemia, hypoxia and oxidative stress after nerve injury has become a research hotspot. The electron absorption and reduction characteristics of fullerenols in biomedical research bring new ideas for the treatment of oxidative stress in the repair of peripheral nerve defects. It seems that the research on fullerenols loaded neural scaffold has great prospects.
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    El Convenio de Oviedo y su adecuación a las nuevas técnicas de intervención del genoma humano.
    (Universidad de Murcia, Servicio de Publicaciones, 2020) Jiménez González, Joaquín
    El Convenio de Oviedo, habiendo supuesto un avance esencial en el derecho internacional de consenso en materia de derechos humanos y biomedicina, veintitrés años después necesita adecuarse a los nuevos avances científicos respecto a las técnicas de intervención de la línea germinal humana. Aceptando que éstas forman parte ya del contexto social, científico y jurídico de nuestra época, y que alguna de ellas necesita aún un intenso debate sobre su aplicación, como las técnicas de edición del genoma, analizamos en el presente trabajo cuales son las modificaciones que consideramos oportunas para que la norma incluya esta realidad y ofrezca mayor seguridad jurídica respecto a estas técnicas.
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    Octodon degus: a natural model of multimorbidity for ageing research
    (Elsevier. Science Direct, 2020-12) Cuenca Bermejo, Lorena; Pizzichini, Elisa; González Cuello, Ana María; De Stefano, María Egle; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad; Enfermería
    Integrating the multifactorial processes co-occurring in both physiological and pathological human conditions still remains one of the main challenges in translational investigation. Moreover, the impact of age-associated disorders has increased, which underlines the urgent need to find a feasible model that could help in the development of successful therapies. In this sense, the Octodon degus has been indicated as a 'natural' model in many biomedical areas, especially in ageing. This rodent shows complex social interactions and high sensitiveness to early-stressful events, which have been used to investigate neurodevelopmental processes. Interestingly, a high genetic similarity with some key proteins implicated in human diseases, such as apolipoprotein-E, β-amyloid or insulin, has been demonstrated. On the other hand, the fact that this animal is diurnal has provided important contribution in the field of circadian biology. Concerning age-related diseases, this rodent could be a good model of multimorbidity since it naturally develops cognitive decline, neurodegenerative histopathological hallmarks, visual degeneration, type II diabetes, endocrinological and metabolic dysfunctions, neoplasias and kidneys alterations. In this review we have collected and summarized the studies performed on the Octodon degus through the years that support its use as a model for biomedical research, with a special focus on ageing.