Publication: Planimetric and histological study
of the aortae in atherosclerotic chickens
treated with nifedipine, verapamil and diltiazem
Authors
García Pérez, Bartolomé ; Ayala de la Peña, Ignacio ; Ortega, M.R. ; Ortega, J.V. ; Ballesta Germán, José ; Fernández Pardo, Jacinto ; Valdés, M ; Castells Mora, María Teresa ; Madrid Cuevas, Juan Francisco
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Calcium appears to be involved in many of
the cellular events which are thought to be important in
atherogenesis. Calcium channel blockers have been
shown to reduce arterial lipid accumulation in animals
without altering serum cholesterol. Avian models of
atherosclerosis offer economic and technical advantages
over mammalian models.
In this study, we examine the effects of nifedipine,
verapamil and diltiazem at clinical and higher doses, on
the extent of atherosclerosis of egg-fed chickens. In
order to assess the extent of atherosclerosis
quantitatively, the aortic lesions of the thoracic and
abdominal aorta, aortic arch and supraaortic regions
were measured by planimetry. Atherosclerotic lesions
were evaluated histologically. Statistically significant
reductions in the lipid deposition of the aorta were found
in all the treated groups. The extent and distribution of
atherosclerotic lesions were decreased in a significant
way by verapamil, nifedipine and diltiazem. The higher
the dosage used, the higher the regression of the
atherosclerotic lesions. At clinical dosage, nifedipine
showed the highest decrease of the lesions. In addition,
the chicken atherosclerosis model has proved itself
useful and very suitable for in vivo drug intervention
studies.
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