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Planimetric and histological study of the aortae in atherosclerotic chickens treated with nifedipine, verapamil and diltiazem

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dc.contributor.authorGarcía Pérez, Bartolomées
dc.contributor.authorAyala de la Peña, Ignacioes
dc.contributor.authorOrtega, M.R.
dc.contributor.authorOrtega, J.V.
dc.contributor.authorBallesta Germán, José
dc.contributor.authorFernández Pardo, Jacinto
dc.contributor.authorValdés, M
dc.contributor.authorCastells Mora, María Teresa
dc.contributor.authorMadrid Cuevas, Juan Francisco
dc.date.accessioned2011-06-08T09:03:56Z
dc.date.available2011-06-08T09:03:56Z
dc.date.issued2003
dc.description.abstractCalcium appears to be involved in many of the cellular events which are thought to be important in atherogenesis. Calcium channel blockers have been shown to reduce arterial lipid accumulation in animals without altering serum cholesterol. Avian models of atherosclerosis offer economic and technical advantages over mammalian models. In this study, we examine the effects of nifedipine, verapamil and diltiazem at clinical and higher doses, on the extent of atherosclerosis of egg-fed chickens. In order to assess the extent of atherosclerosis quantitatively, the aortic lesions of the thoracic and abdominal aorta, aortic arch and supraaortic regions were measured by planimetry. Atherosclerotic lesions were evaluated histologically. Statistically significant reductions in the lipid deposition of the aorta were found in all the treated groups. The extent and distribution of atherosclerotic lesions were decreased in a significant way by verapamil, nifedipine and diltiazem. The higher the dosage used, the higher the regression of the atherosclerotic lesions. At clinical dosage, nifedipine showed the highest decrease of the lesions. In addition, the chicken atherosclerosis model has proved itself useful and very suitable for in vivo drug intervention studies.es
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dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/21481
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAtherosclerosises
dc.subjectNifedipinees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titlePlanimetric and histological study of the aortae in atherosclerotic chickens treated with nifedipine, verapamil and diltiazemes
dc.typeinfo:eu-repo/semantics/articlees
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relation.isAuthorOfPublicationd6ad2235-d5ca-4574-85eb-964da3c5c44c
relation.isAuthorOfPublication773c85c2-1260-4a4d-9543-f5a615648d71
relation.isAuthorOfPublication.latestForDiscoveryd6ad2235-d5ca-4574-85eb-964da3c5c44c
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Histology and histopathology Vol.18, nº 4 (2003)