Publication: Reorganization of the subplasmalemmal cytoskeleton in association with exocytosis in rat mast cells
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Date
1989
Authors
Holm Nielsen, E. ; Braun, K. ; Johansen, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The subplasmalernmal cytoskeleton in mast
cells has been studied by scanning electron microscopy of
the internal side of the plasma membrane. Rearrangement
of the dense subplasmalemmal network of actin
filaments took place following cell activation by compound
48/80 and secretion of histamine. The rearrangement
was a withdrawal of the subplasmalemmal cytoskeleton
from the exocytotic sites and the development of
bare, filament-free areas around the sites. In calciumdepleted
mast cells we demonstrated a dense network
that was difficult to break. Activation of the calciumdepleted
cells by compound 48/80 did not induce rearrangement
of the network, and in parallel there was no
secretion of histamine.
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