Publication:
Exhaled volatile organic compounds analysis in clinical pediatrics: a systematic review

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Date
2020-09-12
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Authors
Pastor Hernández, José M. ; Yanes Torrado, Óscar ; Vinaixa Crevillent, María ; Cánovas Díaz, Manuel ; Diego Puente, Teresa de ; Sola Martínez, Rosa Alba
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Bioquímica y Biología Molecular B e Inmunología
DOI
https://doi.org/10.1038/s41390-020-01116-8
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info:eu-repo/semantics/article
Description
©International Pediatric Research Foundation, Inc. 2020. This document is the Published version of a Published Work that appeared in final form in Pediatric Research. To access the final edited and published work see https://doi.org/10.1038/s41390-020-01116-8
Abstract
BACKGROUND: Measured exhaled volatile organic compounds (VOCs) in breath also referred to as exhaled volatilome have been long claimed as a potential source of non-invasive and clinically applicable biomarkers. However, the feasibility of using exhaled volatilome in clinical practice remains to be demonstrated, particularly in pediatrics where the need for improved non-invasive diagnostic and monitoring methods is most urgent. This work presents the first formal evidence-based judgment of the clinical potential of breath volatilome in the pediatric population. METHODS: A rigorous systematic review across Web of Science, SCOPUS, and PubMed databases following the PRISMA statement guidelines. A narrative synthesis of the evidence was conducted and QUADAS-2 was used to assess the quality of selected studies. RESULTS: Two independent reviewers deemed 22 out of the 229 records initially found to satisfy inclusion criteria. A summary of breath VOCs found to be relevant for several respiratory, infectious, and metabolic pathologies was conducted. In addition, we assessed their associated metabolism coverage through a functional characterization analysis. CONCLUSION: Our results indicate that current research remains stagnant in a preclinical exploratory setting. Designing exploratory experiments in compliance with metabolomics practice should drive forward the clinical translation of VOCs breath analysis
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Citation
Pediatric Research (2021) 89:1352–1363
URI
http://hdl.handle.net/10201/136578
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