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Exhaled volatile organic compounds analysis in clinical pediatrics: a systematic review

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dc.contributor.authorPastor Hernández, José M.
dc.contributor.authorYanes Torrado, Óscar
dc.contributor.authorVinaixa Crevillent, María
dc.contributor.authorCánovas Díaz, Manuel
dc.contributor.authorDiego Puente, Teresa de
dc.contributor.authorSola Martínez, Rosa Alba
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.date.accessioned2023-12-12T23:11:55Z
dc.date.available2023-12-12T23:11:55Z
dc.date.issued2020-09-12
dc.description©International Pediatric Research Foundation, Inc. 2020. This document is the Published version of a Published Work that appeared in final form in Pediatric Research. To access the final edited and published work see https://doi.org/10.1038/s41390-020-01116-8
dc.description.abstractBACKGROUND: Measured exhaled volatile organic compounds (VOCs) in breath also referred to as exhaled volatilome have been long claimed as a potential source of non-invasive and clinically applicable biomarkers. However, the feasibility of using exhaled volatilome in clinical practice remains to be demonstrated, particularly in pediatrics where the need for improved non-invasive diagnostic and monitoring methods is most urgent. This work presents the first formal evidence-based judgment of the clinical potential of breath volatilome in the pediatric population. METHODS: A rigorous systematic review across Web of Science, SCOPUS, and PubMed databases following the PRISMA statement guidelines. A narrative synthesis of the evidence was conducted and QUADAS-2 was used to assess the quality of selected studies. RESULTS: Two independent reviewers deemed 22 out of the 229 records initially found to satisfy inclusion criteria. A summary of breath VOCs found to be relevant for several respiratory, infectious, and metabolic pathologies was conducted. In addition, we assessed their associated metabolism coverage through a functional characterization analysis. CONCLUSION: Our results indicate that current research remains stagnant in a preclinical exploratory setting. Designing exploratory experiments in compliance with metabolomics practice should drive forward the clinical translation of VOCs breath analysis
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dc.format.extent12
dc.identifier.citationPediatric Research (2021) 89:1352–1363
dc.identifier.doihttps://doi.org/10.1038/s41390-020-01116-8
dc.identifier.issn2469-5769
dc.identifier.urihttp://hdl.handle.net/10201/136578
dc.languageenges_ES
dc.relation.isreferencedbyED_IDENTRADA=1269
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.titleExhaled volatile organic compounds analysis in clinical pediatrics: a systematic reviewes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dspace.entity.typePublicationes
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relation.isAuthorOfPublication.latestForDiscovery57bf3537-1124-49ab-8774-bd0c3bdf1c28
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