Publication: New aspects on the role of
lipoxygenases in cancer progression
Authors
Catalano, A. ; Procopio, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The Lipoxygenases (LOXs) are a class of
enzymes that convert arachidonic, linoleic, and other
polyunsaturated fatty acid into biologically active
metabolites involved in the inflammatory and immune
responses. Recent evidences indicate that LOXs and the
signaling pathways that are involved in their activation
are also important for carcinogenesis and tumor
progression. LOXs should therefore receive as much
attention from cancer researchers as it has already from
immunologists. In this article, we will review some
evidence that the LOXs pathways affect several aspects
of lung, pancreatic and prostate cancer progression.
Moreover, we discuss how this new perspective on the
roles of LOXs and their metabolites can have important
implications to cancer therapy.
Citation
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