Publication: Effect of dietary fat on toad liver tumor induced by DMBA. Ultrastructural studies
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Date
1994
Authors
Sadek, I.A. ; Abdul-Salarn, F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Toads injected with 2 mg 7,12-dimethylbenza(
a)anthracene (DMBA)/toad, 3 timeslweek for 12
weeks induced liver tumors in 12 out of 50 cases. The
electron micrograph of toad liver tumor showed
disorganization of the rough endoplasmic reticulum
which encircles or partially surrounds the mitochondria.
Cristae mitochondrialis are rare in comparison with
control. Enhancement of liver tumor incidences (29 out
of 50 cases) by DMBA at the same dose level plus 2cc
corn oilltoad, 3 timeslweek for 12 weeks was detected.
Electronmicrograph of this group showed the same
criteria of malignancy as in the first group. No tumor
incidences were detected in toads fed corn oil only. The
electronmicrograph of liver cells showed a high increase
in glycogen and lipid droplets.
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