DigitalUM :: Browsing by Subject "DMBA"

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Open Access
Effect of dietary fat on toad liver tumor induced by DMBA. Ultrastructural studies
(Murcia : F. Hernández, 1994) Sadek, I.A.; Abdul-Salarn, F.
Toads injected with 2 mg 7,12-dimethylbenza( a)anthracene (DMBA)/toad, 3 timeslweek for 12 weeks induced liver tumors in 12 out of 50 cases. The electron micrograph of toad liver tumor showed disorganization of the rough endoplasmic reticulum which encircles or partially surrounds the mitochondria. Cristae mitochondrialis are rare in comparison with control. Enhancement of liver tumor incidences (29 out of 50 cases) by DMBA at the same dose level plus 2cc corn oilltoad, 3 timeslweek for 12 weeks was detected. Electronmicrograph of this group showed the same criteria of malignancy as in the first group. No tumor incidences were detected in toads fed corn oil only. The electronmicrograph of liver cells showed a high increase in glycogen and lipid droplets.
Open Access
Protein S-100 immunostaining as a diagnostic tool for DMBA-induced melanotic lesions
(Murcia : F. Hernández, 1989) Gómez, Salvador; Vicente, Vicente
In the present study we demonstrate immunohistochemically the presence of S-100 protein in numerous melanotic and amelanotic lesions (benign, premalignant and malignant) induced in albino guineapigs on topical application of the carcinogen. Positive staining was also present in al1 their amelanotic metastases. We reiterate the value of this stain in the diagnosis of melanomas, in particular amelanotic melanomas.