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Human leukocyte antigens in cancer metastasis: Prognostic approach and therapeutic susceptibility

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dc.contributor.authorShahrabi, Saeid
dc.contributor.authorHomaei Hadad, Elham
dc.contributor.authorAmin Asnafi, Ali
dc.contributor.authorMaleki Behzad, Masumeh
dc.contributor.authorEhsanpour, Ali
dc.contributor.authorSaki, Najmaldin
dc.date.accessioned2022-06-08T07:47:09Z
dc.date.available2022-06-08T07:47:09Z
dc.date.issued2019
dc.description.abstractHuman leukocyte antigens (HLA), which are a group of antigen-presenting proteins, are classified into two main groups: classic (including HLA-I, HLA-II, HLA-III) and non-classic. These molecules are expressed on the surface of several immune cells, which contribute to the defense of body against foreign antigens. Changing expressions of these molecules on tumor cells can be related to reduced ability of the immune system in killing tumor cells, as well as metastasis induction of many solid tumors. The purpose of this review article is to assess the possible relationship between changing expressions of HLA molecules with cancer metastasis and relapse. It can be stated that the changes in the expressions of HLA molecules on tumor cells are an important mechanism for tumor cell escape from immune cells. Therefore, these changes can be associated with tumor development, metastasis, or relapse. Given the essential role of HLA molecule expression in cancer metastasis and relapse, identification of prognostic value of these alterations as well as targeting HLA molecules with new therapeutic approaches may lead to the prevention of these complications.es
dc.formatapplication/pdfes
dc.format.extent14es
dc.identifier.citationHistology and Histopathology, Vol.34, nÂş2, (2019)
dc.identifier.doiDOI: 10.14670/HH-18-035
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/121063
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMetastasises
dc.subjectCanceres
dc.subjectHuman Leukocyte Antigenses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleHuman leukocyte antigens in cancer metastasis: Prognostic approach and therapeutic susceptibilityes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34, nÂş2 (2019)