Publication: Human leukocyte antigens in cancer metastasis: Prognostic approach and therapeutic susceptibility
Authors
Shahrabi, Saeid ; Homaei Hadad, Elham ; Amin Asnafi, Ali ; Maleki Behzad, Masumeh ; Ehsanpour, Ali ; Saki, Najmaldin
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-18-035
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info:eu-repo/semantics/article
Description
Abstract
Human leukocyte antigens (HLA), which are
a group of antigen-presenting proteins, are classified into
two main groups: classic (including HLA-I, HLA-II,
HLA-III) and non-classic. These molecules are
expressed on the surface of several immune cells, which
contribute to the defense of body against foreign
antigens. Changing expressions of these molecules on
tumor cells can be related to reduced ability of the
immune system in killing tumor cells, as well as
metastasis induction of many solid tumors. The purpose
of this review article is to assess the possible relationship
between changing expressions of HLA molecules with
cancer metastasis and relapse. It can be stated that the
changes in the expressions of HLA molecules on tumor
cells are an important mechanism for tumor cell escape
from immune cells. Therefore, these changes can be
associated with tumor development, metastasis, or
relapse. Given the essential role of HLA molecule
expression in cancer metastasis and relapse,
identification of prognostic value of these alterations as
well as targeting HLA molecules with new therapeutic
approaches may lead to the prevention of these
complications.
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Citation
Histology and Histopathology, Vol.34, nÂş2, (2019)
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