Publication: The MHC-related protein 1 (MR1) is expressed by a subpopulation of CD38+, IgA+ cells in the human intestinal mucosa
Loading...
Date
2009
Authors
Gozalbo López, Beatriz ; Gomez del Moral, Manuel ; Campos Martín, Yolanda ; Setién, Fernando ; Martín, Paloma ; Bellas, Carmen ; Regueiro, José R. ; Martínez Naves, Eduardo
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
MHC-related 1 (MR1) molecule is a nonclassical
member of the MHC class I family of proteins.
The sequence homology between classical MHC class I
molecules and MR1 is very high, although the MR1
gene is not polymorphic and is highly conserved
between species. MR1 is the restriction molecule of a
sub-population of T lymphocytes, which are CD4-,CD8-
and display conserved TCR a chain. The function of
these cells is currently unknown, but they are believed to
have regulatory properties similar to those of the CD1d
restricted NKT cells.
The MR1 gene is ubiquitously transcribed; however
it is unknown what types of cells express the MR1
protein “in vivo”. In the present work we analyzed the
expression of the MR1 protein using specific antisera
and monoclonal antibodies in different human cell lines,
in primary cells and in mucosal tissues. We found some
lymphoid cell lines that express MR1 on the cell surface
but at levels much lower than the MR1 transfected cell
lines. In addition, we observed that expression of MR1
in the mucosa is restricted to a subpopulation of plasma
cells or plasmablasts, CD38+ or CD138+ and IgA+,
located in the human intestinal mucosa. This suggests a
function for MR1 in the development of IgA producing
plasma cells.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.