Browsing by Subject "Mucosa"
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- PublicationMetadata onlyConocimiento y actitud de los dentistas generales españoles frente a lesiones de la mucosa oral / Vicente Jornet García; directores, María Pía López Jornet, Antonio Velandrino Nicolás, Yolanda Martínez Beneyto.(Murcia : Universidad de Murcia, Departamento de Dermatología, Estomatología, Radiología y Medicina Interna,, 2007) Jornet García, Vicente
- PublicationOpen AccessEstudio clínico prospectivo randomizado doble ciego para valorar la eficacia de los antioxidantes (licopeno y ácido hidroxitirosol) versus placebo en pacientes con síndrome de boca ardiente(2014-02-04) Cano Carrillo, Paula; López Jornet, María Pía; Facultad de MedicinaEl Síndrome de boca ardiente (SBA) se caracteriza por una sensación de ardor, escozor o picor generalizados en la cavidad bucal. Su etiología es desconocida a pesar de que hay indicios de la participación de numerosos factores locales, sistémicos y psicológicos. Objetivo: Comprobar la eficacia clínica del aceite de oliva mas licopeno sobre el ardor y escozor en pacientes con SBA durante 3 meses. Materiales y Métodos: La población de nuestro estudio incluye pacientes diagnosticados de Síndrome de Boca Ardiente en la clínica Odontológica de la Universidad de Murcia. Se trata de un estudio a doble ciego randomizado frente a placebo. Se estudiaron 60 pacientes que cumplían los criterios de inclusión, 30 de los cuales son tratados con aceite de oliva mas licopeno y los 30 restantes con placebo. Se analizaron las variables de sintomatología, calidad de vida oral mediante el OHIP-14 y general SF36, HDA y estrés oxidativo en saliva. Resultados: Respecto al EVA global de ardor disminuye la sintomatología en ambos grupos al aplicar el producto. En relación a la evolución de la calidad de vida, mediante el test OHIP-14, tanto en el grupo tratamiento como en el grupo placebo mejora de forma estadísticamente significativa (p>0,05). Al estudiar la evolución de la ansiedad y depresión, medida por H.A.D, no observamos diferencias estadísticamente significativas durante el seguimiento (p<0,05). La calidad de vida general medida por test SF-36 observamos que dentro del grupo tratamiento sólo hay diferencias significativas en el dominio de dolor corporal; no encontrando ninguna diferencia en el grupo placebo. En el análisis del estrés oxidativo encontramos diferencias significativas en TAA (Actividad antioxidante total) en el grupo tratamiento. Finalmente el drenaje salival presenta una mejoría estadísticamente significativa tanto en el grupo tratamiento como en el grupo placebo tras los 3 meses de estudio. Conclusiones: El perfil bioquímico no se modifica durante el periodo de tratamiento en ninguno de los grupos. El dolor global y la calidad de vida oral, mejoró durante los 3 meses de tratamiento en ambos grupos. Con respecto al estrés oxidativo medido en saliva, encontramos que en TAA (Actividad antioxidante total) hay diferencias significativas en el grupo tratamiento. Prospective clinical study randomized double-blind to assess the effectiveness of antioxidants (lycopene and hydroxytyrosol acid) versus placebo in patients with Burning Mouth Syndrome. ABSTRACT Burning mouth syndrome (BMS) is characterized by a burning, stinging or itching widespread in the oral cavity. Its etiology is unknown although there is evidence of participation of many local factors, systemic and psychological. Objective: To assess the clinical efficacy of lycopene more olive oil on the burning and itching in patients with Burning Mouth Syndrome for 3 months. Materials and Methods: The study population included patients diagnosed with Burning Mouth Syndrome in Clinical Dentistry, University of Murcia. This is a randomized double-blind study versus placebo. We studied 60 patients who met the inclusion criteria, 30 of which are treated with more lycopene olive oil and the remaining 30 placebo. Variables were analyzed symptoms, oral quality of life through the overall OHIP-14 and SF36, HDA and oxidative stress in saliva. Results: Regarding the global EVA burning reduces symptoms in both groups when applying the product. Regarding the evolution of the quality of life through the test OHIP-14, both in the treatment group as in the placebo group improved statistically significantly (p>0.05). By studying the evolution of anxiety and depression, as measured by HAD, no statistically significant differences at follow up (p<0.05). The overall quality of life as measured by SF-36 test in the group observed that treatment only significant differences in the bodily pain domain, finding no difference in the placebo group. In the analysis of oxidative stress significant differences in TAA (total antioxidant activity) in the treatment group. Finally salivary drainage presents a statistically significant improvement in both the treatment group as in the placebo group after 3 months of study. Conclusions: The biochemical profile does not change during the treatment period in either group. Global pain and oral quality of life, improved during the 3 months of treatment in both groups. With regard to oxidative stress measured in saliva found in TAA (total antioxidant activity) there are significant differences in the treatment group.
- PublicationMetadata onlyEstudio clínico-patológico de la cicatrización de heridas provocadas sobre la mucosa del dorso lingual de 186 ratas albinas / Fabio Camacho Alonso; dirección Ambrosio Bermejo Fenoll y Pía López Jornet.(Murcia : Universidad de Murcia, Departamento de Dermatología, Estomatología, Radiología y Medicina Física,, 2004) Camacho Alonso, Fabio
- PublicationOpen AccessEstudio de marcadores salivales y eficacia de la aplicación de antioxidantes naturales en la enfermedad de liquen plano oral(2017-04-26) Aznar Cayuela, Cristina; López Jornet, María Pía; Tvarijomaviciute, Asta; Escuela Internacional de Doctorado
- PublicationOpen AccessEvaluación clínico patológica y biomarcadores de estrés oxidativo en pacientes con liquen plano oral(2014-01-30) Pons-Fuster López, Álvaro; López Jornet, María Pía; Facultad de MedicinaIntroducción El liquen plano oral (LPO) es probablemente la enfermedad no infecciosa más frecuente de la mucosa oral .La prevalencia del liquen plano en la población general se estima entre un 0’2 y un 1’9%. En la actualidad, se considera que la LPO es un proceso inmunológico multifactorial con factores genéticos, psicológicos, infecciosos, etc., que podrían actuar como agentes causales o como precipitantes del proceso. Las manifestaciones clínicas se presentan como patrones (erosivos) ulcerosos, atróficos, reticulares, papulares y en placas. La posible malignización del liquen plano oral (LPO) sigue en la actualidad como un tema de controversia, este riesgo de malignización del liquen plano oral sugiere la realización de nuevas investigaciones a fin de determinar los factores involucrados en este proceso. Objetivos. Los objetivos fueron realizar un estudio clínico de las lesiones de liquen plano oral su asociación con enfermedades autoinmunes e investigar condiciones de estrés Oxidativo en saliva Material y Métodos Se seleccionaron 130 pacientes con liquen plano oral que cumplen los criterios de inclusión .En los 130 pacientes de LPO diagnosticados clínica e histopatologicamente se encontró que el tipo clínico de presentación más frecuente fue el reticular. Resultados Existe una asociación estadísticamente significativa entre la forma de presentación y la sintomatología referida por el paciente . La lesión reticular es la forma más frecuente de LPO que aparece como una red de estrías blancas superpuestas, seguidas de patrones (erosivos) ulcerosos, atróficos y placas. Encontramos la presencia de mayor numero de enfermedades autoinmunes 0.07% (10 /130) en pacientes con OLP que en que el grupo control 0,04% (6 /130) Encontramos, la correlación negativa significativa entre la saliva capacidad antioxidante total y los niveles de MDA en LPO. Conclusión Encontramos la presencia de mayor numero de enfermedades autoinmunes en pacientes con OLP que en que el grupo control.Encontramos, la correlación negativa significativa entre la saliva capacidad antioxidante total y los niveles de MDA en LPO. ABSTRACT Oral Lichen planus (OLP) is probably the most common non-infectious disease of the oral mucosa. Lichen planus prevalence in the general population is estimated between 0.2 and 1.9%. At present, it is considered that the LPO is a multifactorial immune process with genetic, psychological, infections factors which could act as causal agents or as precipitating the process. The clinical manifestations are presented as patterns: Ulcer (erosive), atrophic, reticular, papular and in plaques. The reticular lesion is the most common form of LPO which appears as a network of overlapping white streaks, followed by the ulcer (erosive) patterns, then atrophic and finally, plaques. The LPO appears frequently on both sides of the buccal mucosa, but it can also appear in the tongue, gums, or multiple sites. The malignant potential of OLP continues today as a controversial issue and the risk of malignant transformation of oral lichen planus suggests further research to determine the factors involved in this process. Objectives The objectives of this study were to conduct a clinical study of the lesions of OLP, their association with autoimmune diseases and investigate oxidative stress conditions. Material and Methods A study was conducted in 130 patients with oral lichen planus who met the inclusion criteria who were diagnosed clinically and histopathologically. We found that the most frequent clinical type was the reticular ones. Result There is a statistically significant association between the type of presentation and the symptoms reported by the patient. We found the presence of greater number of autoimmune diseases 0.07 % (10/130) in patients with OLP than in the control group 0.04 % (6/130). We found significant negative correlation between total antioxidant capacity of saliva and MDA levels in LPO Conclusion We found the presence of greater number of autoimmune diseases in patients with OLP than in the control group We found significant negative correlation between total antioxidant capacity of saliva and MDA levels in LPO
- PublicationOpen AccessMorphometric study of healthy jejunal and ileal mucosa in adult and aged subjects(Murcia : F. Hernández, 2010) Trbojević-Stanković, Jasna B.; Milicevic, Novika M.; Milošević, Dragoslav P.; Despotović, Nebojša; Davidovic, Mladen; Erceg, Predrag; Bojic, Božidar; Bojic, Danijela; Svorcan, Petar; Protić, Marijana; Dapcevic, Branka; Miljković, Miloš D.; Milicevic, ŽivanaSmall intestine mucosa is often affected with malabsorptive, autoimmune and inflammatory pathological processes. However, morphometric data on the healthy human small intestine mucosa, especially ileum, are scarce. We aimed to obtain histoquantitative data on the healthy jejunal and ileal mucosa and assess the effects of gender and ageing on these parameters. Computer-aided morphometric analysis was performed on 24 jejunal and 25 ileal biopsy samples collected upon routine endoscopy screening of healthy persons with a family history of intestinal malignancy. Subjects were distributed in four groups according to age and sex: adult (<60 years) and elderly (>60 years) males, and adult (<60 years) and elderly (>60 years) females. Results were statistically analyzed with Mann-Whitney U test. Jejunal mucosal thickness was significantly reduced in elderly subjects (p<0.05), especially in elderly females compared to adult ones (p<0.05). Jejunal villi were significantly wider in adult than in the elderly subjects (p<0.05), whereas ileal villi were significantly wider in elderly compared to adult subjects (p<0.01) and in male compared to female subjects (p<0.05). No statistically significant differences were found in other histoquantitative parameters (mucosa epithelium height, crypt numerical density, villous height, crypts and villous perimeter, diameter and epithelium height) of jejunal and ileal mucosa. This study provides complete morphometric data on the healthy human jejunum and the first relevant data on the healthy ileal mucosa, thus representing a valuable morphometric reference for future histoquantitative studies of human small bowel mucosa in both healthy and disease affected individuals
- PublicationOpen AccessThe MHC-related protein 1 (MR1) is expressed by a subpopulation of CD38+, IgA+ cells in the human intestinal mucosa(Murcia : F. Hernández, 2009) Gozalbo López, Beatriz; Gomez del Moral, Manuel; Campos Martín, Yolanda; Setién, Fernando; Martín, Paloma; Bellas, Carmen; Regueiro, José R.; Martínez Naves, EduardoMHC-related 1 (MR1) molecule is a nonclassical member of the MHC class I family of proteins. The sequence homology between classical MHC class I molecules and MR1 is very high, although the MR1 gene is not polymorphic and is highly conserved between species. MR1 is the restriction molecule of a sub-population of T lymphocytes, which are CD4-,CD8- and display conserved TCR a chain. The function of these cells is currently unknown, but they are believed to have regulatory properties similar to those of the CD1d restricted NKT cells. The MR1 gene is ubiquitously transcribed; however it is unknown what types of cells express the MR1 protein “in vivo”. In the present work we analyzed the expression of the MR1 protein using specific antisera and monoclonal antibodies in different human cell lines, in primary cells and in mucosal tissues. We found some lymphoid cell lines that express MR1 on the cell surface but at levels much lower than the MR1 transfected cell lines. In addition, we observed that expression of MR1 in the mucosa is restricted to a subpopulation of plasma cells or plasmablasts, CD38+ or CD138+ and IgA+, located in the human intestinal mucosa. This suggests a function for MR1 in the development of IgA producing plasma cells.