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The MHC-related protein 1 (MR1) is expressed by a subpopulation of CD38+, IgA+ cells in the human intestinal mucosa

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dc.contributor.authorGozalbo López, Beatrizes
dc.contributor.authorGomez del Moral, Manueles
dc.contributor.authorCampos Martín, Yolanda
dc.contributor.authorSetién, Fernando
dc.contributor.authorMartín, Paloma
dc.contributor.authorBellas, Carmen
dc.contributor.authorRegueiro, José R.
dc.contributor.authorMartínez Naves, Eduardo
dc.date.accessioned2014-01-09T10:37:27Z
dc.date.available2014-01-09T10:37:27Z
dc.date.issued2009
dc.description.abstractMHC-related 1 (MR1) molecule is a nonclassical member of the MHC class I family of proteins. The sequence homology between classical MHC class I molecules and MR1 is very high, although the MR1 gene is not polymorphic and is highly conserved between species. MR1 is the restriction molecule of a sub-population of T lymphocytes, which are CD4-,CD8- and display conserved TCR a chain. The function of these cells is currently unknown, but they are believed to have regulatory properties similar to those of the CD1d restricted NKT cells. The MR1 gene is ubiquitously transcribed; however it is unknown what types of cells express the MR1 protein “in vivo”. In the present work we analyzed the expression of the MR1 protein using specific antisera and monoclonal antibodies in different human cell lines, in primary cells and in mucosal tissues. We found some lymphoid cell lines that express MR1 on the cell surface but at levels much lower than the MR1 transfected cell lines. In addition, we observed that expression of MR1 in the mucosa is restricted to a subpopulation of plasma cells or plasmablasts, CD38+ or CD138+ and IgA+, located in the human intestinal mucosa. This suggests a function for MR1 in the development of IgA producing plasma cells.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/37541
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMucosaes
dc.subjectPlasma celles
dc.subject.other61 - Medicinaes
dc.titleThe MHC-related protein 1 (MR1) is expressed by a subpopulation of CD38+, IgA+ cells in the human intestinal mucosaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24,nº11 (2009)