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Role of androgen receptor expression in non-muscle-invasive bladder cancer: a systematic review and meta-analysis

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dc.contributor.authorSanguedolce, Francesca
dc.contributor.authorCormio, Luigi
dc.contributor.authorCarrieri, Giuseppe
dc.contributor.authorCalò, Beppe
dc.contributor.authorRusso, Davide
dc.contributor.authorMenin, Andrea
dc.contributor.authorPastore, Antonio Luigi
dc.contributor.authorGreco, Francesco
dc.contributor.authorBozzini, Giorgio
dc.contributor.authorGalfano, Antonio
dc.contributor.authorPini, Giovannalberto
dc.contributor.authorPorreca, Angelo
dc.contributor.authorMugavero, Filippo
dc.contributor.authorFalsaperla, Mario
dc.contributor.authorCeruti, Carlo
dc.contributor.authorCindolo, Luca
dc.contributor.authorAntonelli, Alessandro
dc.contributor.authorMinervini, Andrea
dc.date.accessioned2022-11-17T09:21:23Z
dc.date.available2022-11-17T09:21:23Z
dc.date.issued2020
dc.description.abstractIn order to evaluate the potential prognostic/predictive role of androgen receptor (AR) expression in non-muscle-invasive bladder cancer (NMIBC), and whether it may represent a therapeutic target, we conducted a systematic search of the literature using ‘androgen receptor or AR’, ‘testosterone’, ‘bladder cancer’ and ‘non-muscle invasive bladder cancer or NMIBC’ as keywords. Eleven studies met the inclusion/exclusion criteria. No significant association was found between AR status and patients’ gender (p=0.232), tumor size (p=0.975), tumor stage (p=0.237), tumor grade (p=0.444), tumor multicentricity (p=0.397), concomitant CIS (p=0.316) and progression of disease (p=0.397). On the other hand, relative lack of AR expression was significantly correlated to recurrent disease (p=0.001). Evidence for a direct correlation between AR expression and recurrence-free survival of patients with NMIBC indicate ARs as potential markers of BC behavior; moreover, the finding of a role of androgen blockade therapy in improving survival highlights the potential clinical application of this pathway, which deserves to be further explored.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and Histopathology Vol. 35, nº5 (2020)
dc.identifier.doihttps://doi.org/10.14670/HH-18-189
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/125684
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAndrogen receptores
dc.subjectNon-muscle-invasive bladder canceres
dc.subjectImmunohistochemistryes
dc.subjectPrognosises
dc.subjectBiomarkerses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleRole of androgen receptor expression in non-muscle-invasive bladder cancer: a systematic review and meta-analysises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.35, nº5 (2020)