Publication: Effects of alcohol on laminin in rat gastric mucosa
| dc.contributor.author | Rightor, Kathryn S. | es |
| dc.contributor.author | Schmidt, Carmen L. | es |
| dc.date.accessioned | 2011-02-01T08:45:36Z | |
| dc.date.available | 2011-02-01T08:45:36Z | |
| dc.date.issued | 1991 | |
| dc.description.abstract | Following ethanol exposure, tlie gastric surface epithelium often exfoliates. leaving a denuded basal lamina. Viable cells from tlie gland migrate along thc basal lamina to repair the defect. a process known as restitution. Laniinin. the major lion-collagenous glycoprotein of basal laminac, functions in cellular adhesion and migration and. tliereforc. any alteration of this molecule b! ethunol may influence subsequent rcs t i t~~t ionA. fter a 5 o r 60 minutes treatment with saline. 5OCl/ll or 100% ethanol. gastric tissues were removed from fasted female Sprag~~e-Dawlerayt s, fixed in 1% paraformaldehyde and processed in Lowicryl. Once embedded and sectioned. specimens were incubated in anti-laminin followed hy protein A-gold. The area of lamina drnsa from interfoveolal-. pit and gland regions was measured and g,old particles counted. Absolute cthanol caused dirnin~shed imrnunogold binding in all regions at all time periods. except the gland at 60 minutes. Exposure to 50% ethanol for 5 minutes did not alter laminin bincling. although 60 minutes after 50%) alcohol, laminin immunolabelling was increased. Alcohol concentration alters laminin immuno~old binding. and therefore may influence restitituion. | es |
| dc.format | application/pdf | es |
| dc.format.extent | 15 | es |
| dc.identifier.issn | 0213-3911 | es |
| dc.identifier.uri | http://hdl.handle.net/10201/18226 | |
| dc.language | eng | es |
| dc.publisher | Murcia : F. Hernández | es |
| dc.relation.ispartof | Histology and histopathology | es |
| dc.rights | info:eu-repo/semantics/openAccess | es |
| dc.subject | Basal lamina | es |
| dc.subject | Basement membrane | es |
| dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
| dc.title | Effects of alcohol on laminin in rat gastric mucosa | es |
| dc.type | info:eu-repo/semantics/article | es |
| dspace.entity.type | Publication | es |
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