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The clinical translational potential of p53-related alterations as cancer biomarkers

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dc.contributor.authorXiao, Meng
dc.contributor.authorWang, Xu
dc.contributor.authorChen, Wantao
dc.date.accessioned2020-12-16T11:55:54Z
dc.date.available2020-12-16T11:55:54Z
dc.date.issued2015
dc.description.abstractWe aimed to analyse and summarise the potential value of the clinical use of p53-related alterations as cancer biomarkers. A systematic search and collection of the published meta-analyses on p53- related alterations and cancers in the past 5 years was conducted through appropriate queries in the PubMed database. We then composed “grey-scale” tables to show the significant levels for each variant, and the potential heterogeneity was subsequently discussed. The data show that p53-related alterations are extremely complex biomarkers in terms of their clinical translation. Together with the experimental studies on p53-related alterations, a gold-standard approach is still in need of development, with more evidence from clinical studies with large, prospectively planned cohorts, to fully understand its potential as a cancer biomarker.es
dc.formatapplication/pdfes
dc.format.extent18es
dc.identifier.citationHistology and Histopathology, vol. 30, nº 10, (2015)
dc.identifier.doi10.14670/HH-11-637
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/99969
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectp53es
dc.subjectMeta-analysises
dc.subjectCancer biomarkeres
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe clinical translational potential of p53-related alterations as cancer biomarkerses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30,nº10 (2015)