Publication: The clinical translational potential of p53-related alterations as cancer biomarkers
Authors
Xiao, Meng ; Wang, Xu ; Chen, Wantao
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
10.14670/HH-11-637
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info:eu-repo/semantics/article
Description
Abstract
We aimed to analyse and summarise the
potential value of the clinical use of p53-related
alterations as cancer biomarkers. A systematic search
and collection of the published meta-analyses on p53-
related alterations and cancers in the past 5 years was
conducted through appropriate queries in the PubMed
database. We then composed “grey-scale” tables to show
the significant levels for each variant, and the potential
heterogeneity was subsequently discussed. The data
show that p53-related alterations are extremely complex
biomarkers in terms of their clinical translation. Together
with the experimental studies on p53-related alterations,
a gold-standard approach is still in need of development,
with more evidence from clinical studies with large,
prospectively planned cohorts, to fully understand its
potential as a cancer biomarker.
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Citation
Histology and Histopathology, vol. 30, nº 10, (2015)
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/