Publication: Synthesis of Benzofused O- and N‐Heterocycles through Cascade Carbopalladation/Cross-Alkylation of Alkynes Involving the C−C Cleavage of Cyclobutanols
Authors
Pérez-Gómez, Marta ; Herrera-Ramírez, Piedad ; Bautista, Delia ; Saura-LLamas, Isabel ; García-López, José Antonio
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Publisher
American Chemical Society
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DOI
https://doi.org/10.1021/acs.organomet.2c00015
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info:eu-repo/semantics/article
Description
© 2024 American Chemical Society
This document is the accepted version of a published work that appeared in final form in Organometallics
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To access the final edited and published work see: https://doi.org/10.1021/acs.organomet.2c00015
Abstract
We report a Pd-catalyzed route to heterocycles bearing a tetrasubstituted alkene fragment. Our approach merges the intramolecular carbopalladation of tethered alkynes with an alkylation step produced by the C–C cleavage of cyclobutanol derivatives. An alkenyl-Pd(II) intermediate has been isolated and characterized by X-ray diffraction studies. Interestingly, the nature of the tethering alkynyl chain influences the E/Z stereochemistry of the alkenyl fragment in the functionalized heterocycles
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Citation
Organometallics 2022, 41, 649-658
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