Browsing by Subject "Heterociclos"

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    Synthesis of Benzofused O- and N‐Heterocycles through Cascade Carbopalladation/Cross-Alkylation of Alkynes Involving the C−C Cleavage of Cyclobutanols
    (American Chemical Society, 2022-03-03) Pérez-Gómez, Marta; Herrera-Ramírez, Piedad; Bautista, Delia; Saura-LLamas, Isabel; García-López, José Antonio; Química Inorgánica
    We report a Pd-catalyzed route to heterocycles bearing a tetrasubstituted alkene fragment. Our approach merges the intramolecular carbopalladation of tethered alkynes with an alkylation step produced by the C–C cleavage of cyclobutanol derivatives. An alkenyl-Pd(II) intermediate has been isolated and characterized by X-ray diffraction studies. Interestingly, the nature of the tethering alkynyl chain influences the E/Z stereochemistry of the alkenyl fragment in the functionalized heterocycles