Synthesis of Benzofused O- and N‐Heterocycles through Cascade Carbopalladation/Cross-Alkylation of Alkynes Involving the C−C Cleavage of Cyclobutanols

Pérez-Gómez, Marta; Herrera-Ramírez, Piedad; Bautista, Delia; Saura-LLamas, Isabel; García-López, José Antonio

Publication:
Synthesis of Benzofused O- and N‐Heterocycles through Cascade Carbopalladation/Cross-Alkylation of Alkynes Involving the C−C Cleavage of Cyclobutanols

dc.contributor.author	Pérez-Gómez, Marta
dc.contributor.author	Herrera-Ramírez, Piedad
dc.contributor.author	Bautista, Delia
dc.contributor.author	Saura-LLamas, Isabel
dc.contributor.author	García-López, José Antonio
dc.contributor.department	Química Inorgánica
dc.date.accessioned	2025-01-28T17:31:30Z
dc.date.available	2025-01-28T17:31:30Z
dc.date.issued	2022-03-03
dc.description	© 2024 American Chemical Society This document is the accepted version of a published work that appeared in final form in Organometallics , To access the final edited and published work see: https://doi.org/10.1021/acs.organomet.2c00015
dc.description.abstract	We report a Pd-catalyzed route to heterocycles bearing a tetrasubstituted alkene fragment. Our approach merges the intramolecular carbopalladation of tethered alkynes with an alkylation step produced by the C–C cleavage of cyclobutanol derivatives. An alkenyl-Pd(II) intermediate has been isolated and characterized by X-ray diffraction studies. Interestingly, the nature of the tethering alkynyl chain influences the E/Z stereochemistry of the alkenyl fragment in the functionalized heterocycles	es
dc.format	application/pdf	es
dc.format.extent	11	es
dc.identifier.citation	Organometallics 2022, 41, 649-658
dc.identifier.doi	https://doi.org/10.1021/acs.organomet.2c00015
dc.identifier.issn	Print.: 0276-7333
dc.identifier.issn	Electronic.: 1520-6041
dc.identifier.uri	http://hdl.handle.net/10201/149495
dc.language	eng	es
dc.publisher	American Chemical Society	es
dc.relation	Ministerio de Ciencia, Innovación y Universidades (Spain), FEDER “Una manera de hacer Europa” (Project PGC2018-100719-BI00). Fundación Séneca Región de Murcia (19890/GERM/15). MCIN - Ramón y Cajal Fellowship RYC-2016-20137.	es
dc.relation.publisherversion	https://pubs.acs.org/doi/10.1021/acs.organomet.2c00015	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Paladio	es
dc.subject	Ciclobutanol	es
dc.subject	Heterociclos	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::54 - Química::547 - Química orgánica	es
dc.title	Synthesis of Benzofused O- and N‐Heterocycles through Cascade Carbopalladation/Cross-Alkylation of Alkynes Involving the C−C Cleavage of Cyclobutanols	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es