Publication:
The role of TF- and Tn-antigens in breast cancer metastasis

Thumbnail Image
Files
Kolbl-31-613-621-2016.pdf(165.63 KB)
Date
2016
relationships.isAuthorOfPublication
relationships.isSecondaryAuthorOf
relationships.isDirectorOf
Authors
Kölbl, Alexandra C. ; Jeschke, Udo ; Friese, Klaus ; Andergassen, Ulrich
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
DOI: 10.14670/HH-11-722
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Almost 40 years ago, researchers found that the Thomsen-Friedenreich (TF) and the Thomsen nouvelle (Tn) antigens could be detected in carcinoma, but not in healthy tissue. A short time after that it became clear that TF and Tn are precursor molecules of the MN-blood group antigens. In normal tissue TF and Tn are coated by glycosyl structures, thereby forming the glycoproteins which are known to account for the MN-blood group antigens, but in malignant tissue these molecules are uncovered. TF, which has an additional Galectin-residue compared to Tn, is correlated with a more favourable prognosis for patients. On the contrary, patients with Tn-bearing tissues have a worse prognosis for overall and progression-free survival. It is known that TF and Tn are involved in the adhesion of tumour cells to the endothelium via a mechanism recruiting Galectin-3 and MUC-1, which is the first step in metastasis formation. Furthermore, it became clear that this pathway can be blocked by a growing number of molecules, thereby creating ways of therapeutical intervention.
publication.page.subject
Antigen , Breast Cancer , Glycosyltransferase , Metastasis , Mucin , Vaccination
Citation
Histology and histopathology: Vol.31, nº6 (2016)
URI
http://hdl.handle.net/10201/111281
item.page.embargo
Collections
Histology and histopathology Vol.31, nº6 (2016)
Ir a Estadísticas