Publication:
The role of TF- and Tn-antigens in breast cancer metastasis

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dc.contributor.authorKölbl, Alexandra C.
dc.contributor.authorJeschke, Udo
dc.contributor.authorFriese, Klaus
dc.contributor.authorAndergassen, Ulrich
dc.date.accessioned2021-07-23T08:10:19Z
dc.date.available2021-07-23T08:10:19Z
dc.date.issued2016
dc.description.abstractAlmost 40 years ago, researchers found that the Thomsen-Friedenreich (TF) and the Thomsen nouvelle (Tn) antigens could be detected in carcinoma, but not in healthy tissue. A short time after that it became clear that TF and Tn are precursor molecules of the MN-blood group antigens. In normal tissue TF and Tn are coated by glycosyl structures, thereby forming the glycoproteins which are known to account for the MN-blood group antigens, but in malignant tissue these molecules are uncovered. TF, which has an additional Galectin-residue compared to Tn, is correlated with a more favourable prognosis for patients. On the contrary, patients with Tn-bearing tissues have a worse prognosis for overall and progression-free survival. It is known that TF and Tn are involved in the adhesion of tumour cells to the endothelium via a mechanism recruiting Galectin-3 and MUC-1, which is the first step in metastasis formation. Furthermore, it became clear that this pathway can be blocked by a growing number of molecules, thereby creating ways of therapeutical intervention.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and histopathology: Vol.31, nº6 (2016)
dc.identifier.doiDOI: 10.14670/HH-11-722
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/111281
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAntigenes
dc.subjectBreast Canceres
dc.subjectGlycosyltransferasees
dc.subjectMetastasises
dc.subjectMucines
dc.subjectVaccinationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe role of TF- and Tn-antigens in breast cancer metastasises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.31, nº6 (2016)