Browsing by Subject "Antigen"

Now showing 1 - 4 of 4
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    Evaluation of three Immunochromatographic Assays for detection of Legionella pneumophila serogroup 1 Antigen in Urine Samples
    (Sociedad Española de Quimioterapia, 2009) M.J. Muñoz,; M.C. Martínez Toldos; G. Yagüe; M. Segovia; Genética y Microbiología
    The Uni-Gold, the SAS and the Binax NOW immunochro matographic test (ICT) urinary antigen assays for the qualitative detection of Legionella pneumophila serogroup 1 were com pared using 39 unfrozen and nonconcentrated urine samples from patients with Legionnaires´ disease (LD). The Uni-Gold antigen test detected the urinary antigen in 41% (16/39), the SAS antigen test in 61.5% (24/39), and the Binax NOW antigen test in 74.3% (29/39). The Binax NOW ICT assay showed the best results when detecting L. pneumophila urinary antigen.
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    Relación entre ratio digital (2D:4D) y severidad preoperatoria del cáncer de próstata
    (Sociedad Colombiana de Urología, 2018-07-10) Sánchez-Rodríguez, Carlos; Oñate-Celdrán, Julián; García Escudero, Damián; Samper Mateo, Paula; Vilchez Costas, Ana; Torres Roca, Marcos; Maldonado Cárceles, Ana Belén; López Espín, José Juan; Martínez Díaz, Francisco; Mendiola Olivares, Jaime; Torres Cantero, Alberto Manuel; Oftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
    Objetivo La ratio digital del segundo y cuarto dedo de lamano (2D:4D) es unmarcador de la exposición a andrógenos prenatal que presenta un dimorfismo sexual en mamíferos, siendo menor en hombres que en mujeres. El objetivo de nuestro estudio fue analizar la asociación entre la ratio 2D:4D (como marcador indirecto del ambiente hormonal intrauterino) y la severidad preoperatoria del cáncer de próstata (CaP). Material y métodos Se trata de un estudio transversal que incluyó 118 pacientes intervenidos de CaP y con confirmación histológica por biopsia desde abril de 2007 hasta julio de 2015. A cada paciente se le realizó una exploración física y se midió desde la base de la falange proximal hasta el extremo de la falange distal tanto en el cuarto como en el segundo dedo de la mano derecha. La asociación entre la ratio 2D:4D y los indicadores de severidad prequirúrgicos de CaP se realizaron mediante test de medias, correlación de Spearman y regresión lineal simple. Resultados La ratio 2D:4D se asoció significativamente con el PSA prequirúrgico (p ¼ 0,023) y con el porcentaje de cilindros afectados en la biopsia (p ¼ 0,05). Conclusión Nuestros resultados sugieren que una mayor exposición androgénica prenatal, reflejado en una ratio 2D:4D disminuida, estaría asociada con una mayor severidad prequirúrgica del CaP.
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    Sites of lymph follicle formation in the draining popliteal lymph nodes of mice locally injected with antigenic and mitogenic substances
    (Murcia : F. Hernández, 1990) Hee Kyung Ahnl; Hajime Hoshi; Kaeko Horie; Hidetsugu Nagata
    Our previous studies showed that some antigenic and mitogenic substances, when locally injected into mice, efficiently produced new lymph follicles outside pre-exisiting follicles in draining lymph nodes, whereas others had virtually no effect. In the present experiments, young adult male mice were injected with several antigens and mitogens in the rear footpad, and the number and development sites of newly produced lymph follicles in the draining popliteal nodes were studied using serial sections of the nodes obtained between 5 and 21 days after injection. In the unstimulated state, each popliteal node contained a limited number of lymph follicles which mostly lay in a portion of the peripheral cortex overlaying the deep cortex (this portion is referred to as the PCOU), whereas a portion of the peripheral cortex extending beyond the deep cortex (referred to as the PCBU) was underdeveloped with only occasional follicles. Mice treated with soluble PHA or fluid tetanus toxoid developed germinal centers in association with existing follicles but failed to produce new follicles. The PCBU of the draining nodes remained underdeveloped, and the number and distribution pattern of lymph follicles within a draining node were comparable to those in the control node. Animals treated with LPS (50 pg). Con A, alum-precipitated PHA or alum-precipitated tetanus toxoid produced significantly large numbers of new follicles outside pre-existing follicles in the draining nodes, the new follicles produced in the PCBU being generally more numerous than those in the PCOU. In these draining nodes, the peripheral cortex, comprising a number of follicles, was found to overlie the deep cortex and extend beyond the deep cortex towards the hilar region. In animals given a less effective stimulant, such as ferritin or a smaller dose of LPS (10 pg), the draining nodes produced a relatively small number of new follicles, most of which were formed in the PCBU. The present results indicate that in the mouse popliteal node, the PCBU is morphologically underdeveloped under normal conditions. but develops lymph follicles in response to exogenous stimuli more readily than the PCOU, and that substances efficient in inducing follicle formation can be regarded as capable of stimulating the development of the peripheral cortex.
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    The role of TF- and Tn-antigens in breast cancer metastasis
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2016) Kölbl, Alexandra C.; Jeschke, Udo; Friese, Klaus; Andergassen, Ulrich
    Almost 40 years ago, researchers found that the Thomsen-Friedenreich (TF) and the Thomsen nouvelle (Tn) antigens could be detected in carcinoma, but not in healthy tissue. A short time after that it became clear that TF and Tn are precursor molecules of the MN-blood group antigens. In normal tissue TF and Tn are coated by glycosyl structures, thereby forming the glycoproteins which are known to account for the MN-blood group antigens, but in malignant tissue these molecules are uncovered. TF, which has an additional Galectin-residue compared to Tn, is correlated with a more favourable prognosis for patients. On the contrary, patients with Tn-bearing tissues have a worse prognosis for overall and progression-free survival. It is known that TF and Tn are involved in the adhesion of tumour cells to the endothelium via a mechanism recruiting Galectin-3 and MUC-1, which is the first step in metastasis formation. Furthermore, it became clear that this pathway can be blocked by a growing number of molecules, thereby creating ways of therapeutical intervention.