Publication: Current understanding of orofacial tissue derived
mesenchymal stem cells: an immunological perspective
Authors
Ding, Gang ; Niu, Jianyi ; Wei, Fulan
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
Https://doi.org/10.14670/HH-30.255
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info:eu-repo/semantics/article
Description
Abstract
Mesenchymal stem cells (MSCs) are
multipotent non-hematopoietic progenitor cells able to
differentiate into multiple lineages, holding the potential
for replacing damaged and diseased tissues by tissue
regeneration and immunomodulatory functions. So far,
MSCs have been successfully isolated and characterized
from a variety of orofacial tissues, including dental pulp,
periodontal ligament, root apical papilla, gingiva, etc. In
addition to their self-renewal and multipotent
differentiation properties, these orofacial tissue derived
MSCs are also capable of profound immunomodulatory
effects in vitro and in vivo, thus providing a foundation
for their utilization in allogeneic application and in
treating autoimmune diseases and inflammatory
disorders. In this paper, we will review the current
research progress of the immunomodulatory properties
of orofacial tissue derived MSCs and the underlying
mechanisms, emphasizing the effect of these MSCs on
immune cells, which will facilitate the use of such cells
in clinical treatment.
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Citation
Histology and Histopathology, Vol. 30, n.º 3 (2015)
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