Browsing by Subject "Immunomodulation"

Now showing 1 - 4 of 4
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    Current understanding of orofacial tissue derived mesenchymal stem cells: an immunological perspective
    (F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología, 2015) Ding, Gang; Niu, Jianyi; Wei, Fulan
    Mesenchymal stem cells (MSCs) are multipotent non-hematopoietic progenitor cells able to differentiate into multiple lineages, holding the potential for replacing damaged and diseased tissues by tissue regeneration and immunomodulatory functions. So far, MSCs have been successfully isolated and characterized from a variety of orofacial tissues, including dental pulp, periodontal ligament, root apical papilla, gingiva, etc. In addition to their self-renewal and multipotent differentiation properties, these orofacial tissue derived MSCs are also capable of profound immunomodulatory effects in vitro and in vivo, thus providing a foundation for their utilization in allogeneic application and in treating autoimmune diseases and inflammatory disorders. In this paper, we will review the current research progress of the immunomodulatory properties of orofacial tissue derived MSCs and the underlying mechanisms, emphasizing the effect of these MSCs on immune cells, which will facilitate the use of such cells in clinical treatment.
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    Data for compounds included in the article: "Exploring the multifaceted effects of dietary encapsulated piscidin 1 on gilthead seabream (Sparus aurata): from immunomodulation to muscle quality"
    (2026-05-22) Claudia Marín Parra; Marín Parra, Claudia; Espinosa Ruiz, Cristóbal; Coxon, Christopher R.; Esteban Abad, María de los Ángeles; María Ángeles Esteban Abad; Biología Celular e Histología; María Ángeles Esteban Abad
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    Immunomodulatory functions of mesenchymal stem cells and possible mechanisms
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2016) Wang, Qing; Ding, Gang; Xu, Xin
    In addition to their well-studied self-renewal capabilities and multipotent differentiation properties, mesenchymal stem cells (MSCs) have been reported to possess profound immunomodulatory functions both in vitro and in vivo. More and more studies have shown that MSCs are capable of interacting closely with almost all subsets of immune cells, such as T cells, B cells, dendritic cells, natural killer cells, macrophages, and neutrophils etc. The immunomodulatory property of MSCs may shed light on the treatment of a variety of autoimmune and inflammation-related diseases. In this article, we will review the studies on the immunomodulatory and anti-inflammatory functions of MSCs and the mechanisms responsible for the interaction between immune cells and MSCs, which could improve the development of promising approaches for cellmediated immune therapies.
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    Stereological study of splenic tissue com partments in FK506-treated rats
    (Murcia : F. Hernández, 1997) Milicevic, N.M.; Milicevic, Z.
    Model-based stereology was used to study the changes of splenic structure and proportions of splenic tissue compartments in FK506-treated male Wistar rats (0.1 mg/kg three times a week for 14 days). The point-counting method was utilized to study the volume densities of the following tissue compartments: red pulp; white pulp (this compartment was divided in two subcompartments: follicles and periarteriolar lymphocyte sheath); marginal zone; aed connective tissue. The following stereological parameters of lymphoid follicles were also determined: areal numerical density (the number of follicles per mm2 of tissue section); the numerical density (number of follicles per mm3 of tissue); and the mean follicle diameter. After FK506 treatment a significant reduction of volume density of white pulp was observed, which was due to the very prominent decline in the amount of periarteriolar lymphocyte sheath, whereby the cellular density of this tissue compartment was decreased. In the marginal zone of FK506-treated spleens the presence of numerous, large, densely packed lymphoblastic cells of very uniform appearance was registered. These observations are in very good keeping with the changes of splenic morphology registered in cyclosporin Atreated rats, which further documents the parallelism in actions between these imrnunosuppressive agents.