Publication:
Evaluation of rat liver with ARFI elastography: in vivo and ex vivo study

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Date
2019-05-23
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Authors
Carbonell, Guillermo ; Oltra, Lidia ; Garcia Carrillo, Nuria ; Guzmán Aroca, Florentina ; Salazar, Francisco Javier ; Berná Mestre, Juan de Dios ; Martínez Cáceres, Carlos Manuel ; Berná Serna, Juan De Dios ; Tudela Serrano, José
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Publisher
Public Library of Science (PLoS)
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Dermatología, Estomatología, Radiología y Medicina Física
DOI
https://doi.org/10.1371/journal.pone.0217297
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info:eu-repo/semantics/article
Description
© 2019 Carbonell et al. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in PLoS ONE. To access the final edited and published work see https://doi.org/10.1371/journal.pone.0217297
Abstract
The aim of this study was to compare in vivo vs ex vivo liver stiffness in rats with acoustic radiation force impulse (ARFI) elastography using the histological findings as the gold standard. Eighteen male Wistar rats aged 16–18 months were divided into a control group (n = 6) and obese group (n = 12). Liver stiffness was measured with shear wave velocity (SWV) using the ARFI technique both in vivo and ex vivo. The degree of fibrosis, steatosis and liver inflammation was evaluated in the histological findings. Pearson’s correlation coefficient was applied to relate the SWV values to the histological parameters. The SWV values acquired in the ex vivo study were significantly lower than those obtained in vivo (P < 0.004). A significantly higher correlation value between the degree of liver fibrosis and the ARFI elastography assessment was observed in the ex vivo study (r = 0.706, P <0.002), than the in vivo study (r = 0.623, P < 0.05). Assessment of liver stiffness using ARFI elastography yielded a significant correlation between SWV and liver fibrosis in both the in vivo and ex vivo experiments. We consider that by minimising the influence of possible sources of artefact we could improve the accuracy of the measurements acquired with ARFI.
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Ecografía , Liver
Citation
PLoS One, 2019, Vol. 14 (5) : e0217297
URI
http://hdl.handle.net/10201/148668
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