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Evaluation of rat liver with ARFI elastography: in vivo and ex vivo study

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dc.contributor.authorCarbonell, Guillermo
dc.contributor.authorOltra, Lidia
dc.contributor.authorGarcia Carrillo, Nuria
dc.contributor.authorGuzmán Aroca, Florentina
dc.contributor.authorSalazar, Francisco Javier
dc.contributor.authorBerná Mestre, Juan de Dios
dc.contributor.authorMartínez Cáceres, Carlos Manuel
dc.contributor.authorBerná Serna, Juan De Dios
dc.contributor.authorTudela Serrano, José
dc.contributor.departmentDermatología, Estomatología, Radiología y Medicina Física
dc.date.accessioned2025-01-17T09:46:35Z
dc.date.available2025-01-17T09:46:35Z
dc.date.issued2019-05-23
dc.description© 2019 Carbonell et al. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in PLoS ONE. To access the final edited and published work see https://doi.org/10.1371/journal.pone.0217297
dc.description.abstractThe aim of this study was to compare in vivo vs ex vivo liver stiffness in rats with acoustic radiation force impulse (ARFI) elastography using the histological findings as the gold standard. Eighteen male Wistar rats aged 16–18 months were divided into a control group (n = 6) and obese group (n = 12). Liver stiffness was measured with shear wave velocity (SWV) using the ARFI technique both in vivo and ex vivo. The degree of fibrosis, steatosis and liver inflammation was evaluated in the histological findings. Pearson’s correlation coefficient was applied to relate the SWV values to the histological parameters. The SWV values acquired in the ex vivo study were significantly lower than those obtained in vivo (P < 0.004). A significantly higher correlation value between the degree of liver fibrosis and the ARFI elastography assessment was observed in the ex vivo study (r = 0.706, P <0.002), than the in vivo study (r = 0.623, P < 0.05). Assessment of liver stiffness using ARFI elastography yielded a significant correlation between SWV and liver fibrosis in both the in vivo and ex vivo experiments. We consider that by minimising the influence of possible sources of artefact we could improve the accuracy of the measurements acquired with ARFI.es
dc.formatapplication/pdfes
dc.format.extent15es
dc.identifier.citationPLoS One, 2019, Vol. 14 (5) : e0217297
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0217297
dc.identifier.issnElectronic: 1932-6203
dc.identifier.urihttp://hdl.handle.net/10201/148668
dc.languageenges
dc.publisherPublic Library of Science (PLoS)es
dc.relationProyecto Nacional. Entidad Financiadora: Ministerio de Economía y Competitividad-Instituto de Salud Carlos III Convocatoria 2016: PROYECTOS DE INVESTIGACIÓN EN SALUD. Nombre del proyecto: Mecanismos implicados en la programación fetal de la enfermedad cardiovascular y renal. Estudio Clínico-Experimental. IP: Francisco Xavier Salazar Aparicio.1 de enero de 2017 al 31 de diciembre de 2019 (36 meses). Cuantía: 159.115,00 euros. Proyecto: PI16/01556es
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217297
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectEcografíaes
dc.subjectLiveres
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiologíaes
dc.titleEvaluation of rat liver with ARFI elastography: in vivo and ex vivo studyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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relation.isAuthorOfPublicationb2db368b-5d8f-490c-bc1e-21b04b875f4f
relation.isAuthorOfPublication6891518d-b228-485b-a2ad-6db32b6c4e9f
relation.isAuthorOfPublication.latestForDiscoverya11bfbe4-fe50-4173-a96d-aa785375a6be
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