Publication: Mononuclear cell infiltrate, HLA-Dr expression and proliferation in 37 acoustic schwannomas
Date
1990
Authors
Rossi, M.L. ; Jones, N.R. ; Esiri, M.M. ; Havas, L. ; Nakamura, N. ; Coakham, H.B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Frozen sections from 37 schwannomas
of the V111 nerve were reacted with a panel of
monoclonal antibodies to macrophage, lymphocyte,
I-ILA-Dr invariant chain and nuclear proliferation
antigens. A moderate number of rnacrophages was
demonstrated in 96% of tumours. CD8- and CD4-
lymphocytes were detected in slightly smaller numbers
in up to 87% and 23% of tumours respectively.
B-lyrnphocytes were present in only 2/32 cases
and NK-cells were absent from all 16 cases tested.
HLA-Dr antigen was expressed by macrophages in most
cases and by tumour cells in 13/24 tumours. These
findings may represent evidence for a degree of cellular
immune response. Occasional cells featuring nuclear
proliferation were detected in 15/27 cases.
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Citation
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