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Mononuclear cell infiltrate, HLA-Dr expression and proliferation in 37 acoustic schwannomas

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dc.contributor.authorRossi, M.L.es
dc.contributor.authorJones, N.R.es
dc.contributor.authorEsiri, M.M.
dc.contributor.authorHavas, L.
dc.contributor.authorNakamura, N.
dc.contributor.authorCoakham, H.B.
dc.date.accessioned2011-02-01T08:44:59Z
dc.date.available2011-02-01T08:44:59Z
dc.date.issued1990
dc.description.abstractFrozen sections from 37 schwannomas of the V111 nerve were reacted with a panel of monoclonal antibodies to macrophage, lymphocyte, I-ILA-Dr invariant chain and nuclear proliferation antigens. A moderate number of rnacrophages was demonstrated in 96% of tumours. CD8- and CD4- lymphocytes were detected in slightly smaller numbers in up to 87% and 23% of tumours respectively. B-lyrnphocytes were present in only 2/32 cases and NK-cells were absent from all 16 cases tested. HLA-Dr antigen was expressed by macrophages in most cases and by tumour cells in 13/24 tumours. These findings may represent evidence for a degree of cellular immune response. Occasional cells featuring nuclear proliferation were detected in 15/27 cases.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18184
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCellular immunityes
dc.subjectLymphocytees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nerviosoes
dc.titleMononuclear cell infiltrate, HLA-Dr expression and proliferation in 37 acoustic schwannomases
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 5, nº 4 (1990)