Publication: Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys
Authors
Heman, Paola ; Barcia, Carlos ; Gómez, Aurora ; Ros, Carmen M. ; Ros Bernal, Francisco ; Yuste Jiménez, José Enrique ; Pablos, Vicente de ; Fernández Villalba, Emiliano ; Toledo Cárdenas, María Rebeca ; Herrero Ezquerro, María Trinidad
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of chronic parkinsonian macaques, characterized by the expression of c-Fos, which correlated with dopaminergic degeneration. These results are compatible with the results observed in fMRI in Parkinson’s disease patients, and may contribute to the understanding of additional alterations in the brain circuitry in Parkinsonism
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Citation
Histology and histopathology, Vol. 27, nº 1 (2012)
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