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Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys

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dc.contributor.authorHeman, Paola
dc.contributor.authorBarcia, Carlos
dc.contributor.authorGómez, Aurora
dc.contributor.authorRos, Carmen M.
dc.contributor.authorRos Bernal, Francisco
dc.contributor.authorYuste Jiménez, José Enrique
dc.contributor.authorPablos, Vicente de
dc.contributor.authorFernández Villalba, Emiliano
dc.contributor.authorToledo Cárdenas, María Rebeca
dc.contributor.authorHerrero Ezquerro, María Trinidad
dc.date.accessioned2017-03-08T16:27:26Z
dc.date.available2017-03-08T16:27:26Z
dc.date.issued2012
dc.description.abstractIn the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of chronic parkinsonian macaques, characterized by the expression of c-Fos, which correlated with dopaminergic degeneration. These results are compatible with the results observed in fMRI in Parkinson’s disease patients, and may contribute to the understanding of additional alterations in the brain circuitry in Parkinsonismes
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dc.format.extent6es
dc.identifier.citationHistology and histopathology, Vol. 27, nº 1 (2012)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/52378
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectParkinson´s diseasees
dc.subjectCerebellumes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nerviosoes
dc.titleNigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeyses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication9bbe7af5-429b-4029-b621-0399a6838322
relation.isAuthorOfPublication.latestForDiscovery9bbe7af5-429b-4029-b621-0399a6838322
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Histology and histopathology Vol.27, nº 1 (2012)