Publication: Alveolar cells in cyclophosphamideinduced lung injury_ An ultrastructural
analysis of type II alveolar epithelial cells in situ
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Date
1998
Authors
Sulkowska, M. ; Sulkowski, S.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Recent studies have brought rich evidence in
favour of the significant contribution of the surfactant
system-forming structures to morphogenesis of many
pulmonary disorders. The aim of this study was to
evaluate the effect of intraperitoneal cyclophosphamide
administration on changes within this system.
The experiments used 40 Wistar rats, of 170g body
weight. The animals were divided into two experimental
groups. Group I animals were given cyclophosphamide
(Endoxan-ASTA) in a single intraperitoneal dose of
150mg/1kg b.w./1ml PBS/. Group II (control) received
1ml PBS. All the animals were sacrificed after 1, 3, 7
and 28 days following intraperitoneal cyclophosphamide
or PBS administration. Morphological examinations of
pulmonary tissue were based on ultrastructural analysis
in the transmission electron microscope.
The study revealed that a single intraperitoneal
cyclophosphamide injection caused damage to all
elements forming the surfactant system, particularly to
type II alveolar epithelial cells. Rebuilding processes in
pulmonary tissue, coexisting with destructive changes,
occurred with a significant contribution of type II
alveolar epithelial cells. These cells are likely to take an
active part in pulmonary fibrosis processes observed
after the action of cyclophosphamide.
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Citation
Histology and histopathology, Vol. 13, nº 1 (1998)
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