Publication: Mesenchymal stromal cell therapy for damaged retinal ganglion cells, is gold all that glitters?
Authors
Lucas Ruiz, Fernando ; Galindo Romero, Caridad ; García Bernal, David ; Norte Muñoz, María ; Rodríguez Ramírez, Kristy T. ; Salinas Navarro, Manuel Ángel ; Millán Rivero, José E. ; Vidal Sanz, Manuel ; Agudo Barriuso, Marta
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Publisher
Wolters Kluwer – Medknow Publications
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DOI
https://doi.org/10.4103/1673-5374.259601
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info:eu-repo/semantics/article
Description
Abstract
Mesenchymal stromal cells are an excellent source of stem cells because they are isolated from adult tissues or perinatal derivatives, avoiding the ethical concerns that encumber embryonic stem cells. In preclinical models, it has been shown that mesenchymal stromal cells have neuroprotective and immunomodulatory properties, both of which are ideal for central nervous system treatment and repair. Here we will review the current literature on mesenchymal stromal cells, focusing on bone marrow mesenchymal stromal cells, adipose-derived mesenchymal stromal cells and mesenchymal stromal cells from the umbilical cord stroma, i.e., Wharton’s jelly mesenchymal stromal cells. Finally, we will discuss the use of these cells to alleviate retinal ganglion cell degeneration following axonal trauma.
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Citation
Lucas-Ruiz, F., Galindo-Romero, C., García-Bernal, D., Norte-Muñoz, M., Rodríguez-Ramírez, K. T., Salinas-Navarro, M., ... & Agudo-Barriuso, M. (2019). Mesenchymal stromal cell therapy for damaged retinal ganglion cells, is gold all that glitters?. Neural regeneration research, 14(11), 1851-1857.
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