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Mesenchymal stromal cell therapy for damaged retinal ganglion cells, is gold all that glitters?

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dc.contributor.authorLucas Ruiz, Fernando
dc.contributor.authorGalindo Romero, Caridad
dc.contributor.authorGarcía Bernal, David
dc.contributor.authorNorte Muñoz, María
dc.contributor.authorRodríguez Ramírez, Kristy T.
dc.contributor.authorSalinas Navarro, Manuel Ángel
dc.contributor.authorMillán Rivero, José E.
dc.contributor.authorVidal Sanz, Manuel
dc.contributor.authorAgudo Barriuso, Marta
dc.contributor.departmentAnatomía Humana y Psicobiología
dc.date.accessioned2026-03-05T09:36:42Z
dc.date.available2026-03-05T09:36:42Z
dc.date.copyright© 2019 Neural Regeneration Research
dc.date.issued2019-11-01
dc.description.abstractMesenchymal stromal cells are an excellent source of stem cells because they are isolated from adult tissues or perinatal derivatives, avoiding the ethical concerns that encumber embryonic stem cells. In preclinical models, it has been shown that mesenchymal stromal cells have neuroprotective and immunomodulatory properties, both of which are ideal for central nervous system treatment and repair. Here we will review the current literature on mesenchymal stromal cells, focusing on bone marrow mesenchymal stromal cells, adipose-derived mesenchymal stromal cells and mesenchymal stromal cells from the umbilical cord stroma, i.e., Wharton’s jelly mesenchymal stromal cells. Finally, we will discuss the use of these cells to alleviate retinal ganglion cell degeneration following axonal trauma.
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dc.identifier.citationLucas-Ruiz, F., Galindo-Romero, C., García-Bernal, D., Norte-Muñoz, M., Rodríguez-Ramírez, K. T., Salinas-Navarro, M., ... & Agudo-Barriuso, M. (2019). Mesenchymal stromal cell therapy for damaged retinal ganglion cells, is gold all that glitters?. Neural regeneration research, 14(11), 1851-1857.
dc.identifier.doihttps://doi.org/10.4103/1673-5374.259601
dc.identifier.eissn1876-7958
dc.identifier.issn1673-5374
dc.identifier.urihttp://hdl.handle.net/10201/218361
dc.languageeng
dc.publisherWolters Kluwer – Medknow Publications
dc.relationThis work was supported by the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III (ISCIII), Fondo Europeo de Desarrollo Regional “Una Manera de Hacer Europa” (SAF2015-67643-P to MVS and PI16/00031 to MAB) and Fundación Séneca, Agencia de Ciencia y Tecnología Región de Murcia (19881/GERM/15 to MVS).
dc.relation.publisherversionhttps://journals.lww.com/nrronline/fulltext/2019/14110/mesenchymal_stromal_cell_therapy_for_damaged.2.aspx
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAdipose stem cells
dc.subjectUmbilical cord
dc.subjectStem cells
dc.subjectBone marrow
dc.subjectWharton's jelly
dc.subjectOptic nerve axotomy
dc.subjectNeuroprotection
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleMesenchymal stromal cell therapy for damaged retinal ganglion cells, is gold all that glitters?
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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