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Histopathology and clinical assessment correlate with the cysteine-serine-valinethreonine- cysteine-glycine (CSVTCG) receptor of thrombospondin-1 in breast tumors

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dc.contributor.authorRoth, J.J.es
dc.contributor.authorReiver, D.M.es
dc.contributor.authorGranick, M.S.
dc.contributor.authorRothman, V.L.
dc.contributor.authorNicosia, R.F.
dc.contributor.authorTuszynski, G.P.
dc.date.accessioned2011-02-22T10:42:19Z
dc.date.available2011-02-22T10:42:19Z
dc.date.issued1997
dc.description.abstractThrombospondin-1 (TSP-1) is a matrix protein implicated in mechanisms of tumor metastasis. TSP-1 has a characteristic Cysteine-Serine-Valine- Threonine-Cysteine-Glycine (CSVTCG) sequence that functions as a tumor cell adhesion domain. Our laboratory has isolated a novel CSVTCG specific tumor cell receptor. Immunohistochemical staining techniques and computerized image analysis were used to identify and quantitate the CSVTCG receptor of TSP-1 in a wide spectrum of human archiva1 breast tumors. Histopathologic and quantitative examination was correlated with clinical findings two years post operation. Increasing amounts of CSVTCG receptor correlated positively with worsening histopathologic and clinical findings. These findings suggest a role for the TSP-1 CSVTCG receptor in breast tumor progression. This receptor may have utility for the diagnosis, staging, and treatrnent of this common and deadly disease.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18993
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectBreast tumorses
dc.subjectCanceres
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleHistopathology and clinical assessment correlate with the cysteine-serine-valinethreonine- cysteine-glycine (CSVTCG) receptor of thrombospondin-1 in breast tumorses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.12, nº 4 (1997)