Publication: Histopathology and clinical assessment correlate with the cysteine-serine-valinethreonine-
cysteine-glycine (CSVTCG) receptor
of thrombospondin-1 in breast tumors
Authors
Roth, J.J. ; Reiver, D.M. ; Granick, M.S. ; Rothman, V.L. ; Nicosia, R.F. ; Tuszynski, G.P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Thrombospondin-1 (TSP-1) is a matrix
protein implicated in mechanisms of tumor metastasis.
TSP-1 has a characteristic Cysteine-Serine-Valine-
Threonine-Cysteine-Glycine (CSVTCG) sequence that
functions as a tumor cell adhesion domain. Our
laboratory has isolated a novel CSVTCG specific tumor
cell receptor. Immunohistochemical staining techniques
and computerized image analysis were used to identify
and quantitate the CSVTCG receptor of TSP-1 in a wide
spectrum of human archiva1 breast tumors. Histopathologic
and quantitative examination was correlated
with clinical findings two years post operation.
Increasing amounts of CSVTCG receptor correlated
positively with worsening histopathologic and clinical
findings. These findings suggest a role for the TSP-1
CSVTCG receptor in breast tumor progression. This
receptor may have utility for the diagnosis, staging, and
treatrnent of this common and deadly disease.
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