Publication:
The low density lipoprotein receptor-related protein (LRP) 1 and its function in lung diseases

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Wujak-31-733-745-2016.pdf(3.28 MB)
Date
2016
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Authors
Wujak, L. ; Markart, P. ; Wygrecka, M.
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Publisher
Universidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­a
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DOI
DOI: 10.14670/HH-11-746
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info:eu-repo/semantics/article
Description
Abstract
The low density lipoprotein receptor-related protein (LRP) 1 is a ubiquitously expressed, versatile cell surface transmembrane receptor involved in embryonic development and adult tissue homeostasis. LRP1 binds and endocytoses a broad spectrum of over 40 ligands identified thus far, including lipoproteins, extracellular matrix proteins, proteases and protease/ inhibitor complexes and growth factors. Interactions with other membrane receptors and intracellular adaptors/scaffolding proteins allow LRP1 to modulate cell migration, survival, proliferation and (trans) differentiation. Because LRP1 displays a wide-range of interactions and activities, its expression and function is temporally and spatially tightly controlled. It is not, therefore, surprising that deregulation of LRP1 production and/or activity is observed in several diseases. In this review, we will systematically examine the evidence for the role of LRP1 in human pathologies placing special emphasis on LRP1-mediated pathogenesis of the lung.
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Low density lipoprotein receptor-related protein 1 , Extracellular matrix , Proteases , Lung
Citation
Histology and histopathology, Vol.31, nÂş7 (2016)
URI
http://hdl.handle.net/10201/111404
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Histology and histopathology Vol.31, nÂş7 (2016)
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