Browsing by Subject "Proteases"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Open Access
    Proteasas extracelulares de una cepa enterotoxigenica de Vibrio cholerae no 0:l
    (Murcia: Universidad de Murcia, Servicio de Publicaciones, 1986) Navarro, J. M.; Gacto Fernández, Mariano José; Facultad de Biología
    The alkaline proteolytic system from a non-agglutinable strain of V. cholerae isolated from water has been analysed. Maximal levels of extracellular protease activity are produced during the stationary phase of growth. The proteolytic activity of the system shows a high stability and their synthesis appears to be partially repressed by glucose. The enzyme system is compossed of four distinct proteolytic enzymes as evidenced by SDS-polyacrylamide gel electrophoresis with copolymerized gelatin as substrate.
  • Thumbnail Image
    Publication
    Open Access
    The low density lipoprotein receptor-related protein (LRP) 1 and its function in lung diseases
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2016) Wujak, L.; Markart, P.; Wygrecka, M.
    The low density lipoprotein receptor-related protein (LRP) 1 is a ubiquitously expressed, versatile cell surface transmembrane receptor involved in embryonic development and adult tissue homeostasis. LRP1 binds and endocytoses a broad spectrum of over 40 ligands identified thus far, including lipoproteins, extracellular matrix proteins, proteases and protease/ inhibitor complexes and growth factors. Interactions with other membrane receptors and intracellular adaptors/scaffolding proteins allow LRP1 to modulate cell migration, survival, proliferation and (trans) differentiation. Because LRP1 displays a wide-range of interactions and activities, its expression and function is temporally and spatially tightly controlled. It is not, therefore, surprising that deregulation of LRP1 production and/or activity is observed in several diseases. In this review, we will systematically examine the evidence for the role of LRP1 in human pathologies placing special emphasis on LRP1-mediated pathogenesis of the lung.