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Mechanisms of pre-mRNA splicing, classical versus non-classical pathways

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dc.contributor.authorZaphiropoulos, P.G.es
dc.date.accessioned2011-02-22T10:58:21Z
dc.date.available2011-02-22T10:58:21Z
dc.date.issued1998
dc.description.abstractExpression of genetic information proceeds through two major biological events, transcription and translation. However, in eukaryotic cells, the primary transcript (pre-mRNA) is not the template that the translational apparatus scans through, in order to produce the corresponding protein. Pre-mRNAs undergo several modifications (cap site addition, poly At tail addition) prior to becoming mature mRNAs, with the most important one being the excision (splicing) of the intronic sequences. Yet, the mechanisms that regulate the splicing process and the generation of alternatively spliced mRNA products are still poorly understood. Moreover recent findings suggest that this process also has the capability to produce an additional set of RNA products that differ from typical mRNA molecules. In these novel RNA transcripts the order of the exons has been changed relative to genomic DNA. Furthermore, the properties of these transcripts suggest that they may represent circular RNA molecules.es
dc.formatapplication/pdfes
dc.format.extent5es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19045
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectExon definitiones
dc.subjectExon juxtapositiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleMechanisms of pre-mRNA splicing, classical versus non-classical pathwayses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.13, nº 2 (1998)