Publication: Mechanisms of pre-mRNA splicing, classical versus non-classical pathways
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Date
1998
Authors
Zaphiropoulos, P.G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Expression of genetic information proceeds
through two major biological events, transcription and
translation. However, in eukaryotic cells, the primary
transcript (pre-mRNA) is not the template that the
translational apparatus scans through, in order to
produce the corresponding protein. Pre-mRNAs undergo
several modifications (cap site addition, poly At tail
addition) prior to becoming mature mRNAs, with the
most important one being the excision (splicing) of the
intronic sequences. Yet, the mechanisms that regulate the
splicing process and the generation of alternatively
spliced mRNA products are still poorly understood.
Moreover recent findings suggest that this process also
has the capability to produce an additional set of RNA
products that differ from typical mRNA molecules. In
these novel RNA transcripts the order of the exons has
been changed relative to genomic DNA. Furthermore,
the properties of these transcripts suggest that they may
represent circular RNA molecules.
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