Publication: Sarcomatoid acquired cystic disease-associated renal cell carcinoma
Loading...
Date
2008
Authors
Kuroda, Naoto ; Tamura, Masato ; Taguchi, Takahiro ; Tominaga, Akira ; Hes, Ondrej ; Michal, Michal ; Ohara, Masahiko ; Hirouchi, Takashi ; Mizuno, Keiko ; Hayashi, Yoshihiro ; Shuin, Taro ; Lee, Gang-Hong
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
In this article, we report a rare case of
hitherto undescribed acquired cystic disease (ACD)-
associated renal cell carcinoma (RCC) with sarcomatoid
change. A 78-year-old woman had been receiving
hemodialysis for fourteen years at the time when a renal
tumor was encountered on the follow-up examination of
the kidney. Microscopically, oncocytic cuboidal cells
proliferated with tubular, cribriform or papillary growth
patterns, and atypical columnar cells with abundant
cytoplasm proliferated with papillary configuration.
Oxalate crystal deposition was observed in the stroma
and the tumor focally resembled translocation type
(TFE3) RCC. Sarcomatous neoplastic cells were also
seen. The cytoplasm of oncocytic and sarcomatous
neoplastic cells was diffusely positive for antimitochondrial
antibody and the ultrastructural
examination detected many mitochondria in the
cytoplasm of oncocytic carcinoma cells and sarcomatous
neoplastic cells. The loss of chromosomes 1p, 2q11-22,
9 and 14 was observed using comparative genomic
hybridization analysis. We thus report here a case of
hitherto undescribed ACD-associated RCC intermingled with oncocytic cells, translocation type RCC-like area
and sarcomatoid change. This is the sixth case of
sarcomatoid RCC arising in end-stage kidney disease.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.