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Sarcomatoid acquired cystic disease-associated renal cell carcinoma

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dc.contributor.authorKuroda, Naotoes
dc.contributor.authorTamura, Masatoes
dc.contributor.authorTaguchi, Takahiro
dc.contributor.authorTominaga, Akira
dc.contributor.authorHes, Ondrej
dc.contributor.authorMichal, Michal
dc.contributor.authorOhara, Masahiko
dc.contributor.authorHirouchi, Takashi
dc.contributor.authorMizuno, Keiko
dc.contributor.authorHayashi, Yoshihiro
dc.contributor.authorShuin, Taro
dc.contributor.authorLee, Gang-Hong
dc.date.accessioned2013-01-22T10:04:44Z
dc.date.available2013-01-22T10:04:44Z
dc.date.issued2008
dc.description.abstractIn this article, we report a rare case of hitherto undescribed acquired cystic disease (ACD)- associated renal cell carcinoma (RCC) with sarcomatoid change. A 78-year-old woman had been receiving hemodialysis for fourteen years at the time when a renal tumor was encountered on the follow-up examination of the kidney. Microscopically, oncocytic cuboidal cells proliferated with tubular, cribriform or papillary growth patterns, and atypical columnar cells with abundant cytoplasm proliferated with papillary configuration. Oxalate crystal deposition was observed in the stroma and the tumor focally resembled translocation type (TFE3) RCC. Sarcomatous neoplastic cells were also seen. The cytoplasm of oncocytic and sarcomatous neoplastic cells was diffusely positive for antimitochondrial antibody and the ultrastructural examination detected many mitochondria in the cytoplasm of oncocytic carcinoma cells and sarcomatous neoplastic cells. The loss of chromosomes 1p, 2q11-22, 9 and 14 was observed using comparative genomic hybridization analysis. We thus report here a case of hitherto undescribed ACD-associated RCC intermingled with oncocytic cells, translocation type RCC-like area and sarcomatoid change. This is the sixth case of sarcomatoid RCC arising in end-stage kidney disease.es
dc.formatapplication/pdfes
dc.format.extent5es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/29858
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectRenal cell carcinomaes
dc.subjectSarcomaes
dc.subject.other616.6 - Patología del sistema genitourinarioes
dc.titleSarcomatoid acquired cystic disease-associated renal cell carcinomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.23,nº11 (2008)