Publication: Beneficial effects of cannabinoid receptor type 2 (CB2R) in injured skeletal muscle post-contusion
Authors
Yu, Tianshui ; Wang, Xu ; Zhao, Rui ; Zheng, Jilong ; Li, Liqiang ; Ma, Wenxiang ; Zhang, Shutao Zhang ; Guan, Dawei
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
10.14670/HH-30.737
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info:eu-repo/semantics/article
Description
Abstract
The aim of the current study was to
investigate the effects of cannabinoid receptor type 2
(CB2R) on the repair process of injured skeletal muscle,
which could potentially lay solid foundations as a novel
target for curing muscular fibrosis in future. A
standardized rat model of skeletal muscle contusion was
established, where rats were treated with the CB2R
agonist JWH-133 or antagonist AM-630. The in vivo
results revealed that CB2R activation with JWH-133
significantly diminished the fibrotic areas, downregulated the mRNA levels of collagen type I/ІІІ and
augmented the number of multinucleated regenerating
myofibers in the injured zones. The reasons leading to
the aforementioned results were directly attributable to
decreased mRNA levels of TGF-β1, FN-EIIIA and αSMA, reduced accumulation of myofibroblasts, and
concomitantly increased mRNA levels of matrix
metalloproteinase-1/2. However, we observed
contrasting changes in rats treated with the CB2R
antagonist AM-630. These results revealed multiple
effects of CB2R in systematically inhibiting fibrotic
formation and improving muscle regeneration, alongside
its potential for clinical application in patients with
skeletal muscle injuries and diseases.
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Citation
Histology and Histopathology, vol.30, nº 6, (2015)
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