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Beneficial effects of cannabinoid receptor type 2 (CB2R) in injured skeletal muscle post-contusion

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dc.contributor.authorYu, Tianshui
dc.contributor.authorWang, Xu
dc.contributor.authorZhao, Rui
dc.contributor.authorZheng, Jilong
dc.contributor.authorLi, Liqiang
dc.contributor.authorMa, Wenxiang
dc.contributor.authorZhang, Shutao Zhang
dc.contributor.authorGuan, Dawei
dc.date.accessioned2020-09-18T11:58:05Z
dc.date.available2020-09-18T11:58:05Z
dc.date.issued2015
dc.description.abstractThe aim of the current study was to investigate the effects of cannabinoid receptor type 2 (CB2R) on the repair process of injured skeletal muscle, which could potentially lay solid foundations as a novel target for curing muscular fibrosis in future. A standardized rat model of skeletal muscle contusion was established, where rats were treated with the CB2R agonist JWH-133 or antagonist AM-630. The in vivo results revealed that CB2R activation with JWH-133 significantly diminished the fibrotic areas, downregulated the mRNA levels of collagen type I/ІІІ and augmented the number of multinucleated regenerating myofibers in the injured zones. The reasons leading to the aforementioned results were directly attributable to decreased mRNA levels of TGF-β1, FN-EIIIA and αSMA, reduced accumulation of myofibroblasts, and concomitantly increased mRNA levels of matrix metalloproteinase-1/2. However, we observed contrasting changes in rats treated with the CB2R antagonist AM-630. These results revealed multiple effects of CB2R in systematically inhibiting fibrotic formation and improving muscle regeneration, alongside its potential for clinical application in patients with skeletal muscle injuries and diseases.es
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dc.format.extent13es
dc.identifier.citationHistology and Histopathology, vol.30, nº 6, (2015)
dc.identifier.doi10.14670/HH-30.737
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/96145
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMuscle injuryes
dc.subjectFibrosises
dc.subjectRegenerationes
dc.subjectCannabinoid receptor type 2 (CB2R)es
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleBeneficial effects of cannabinoid receptor type 2 (CB2R) in injured skeletal muscle post-contusiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº6 (2015)