Publication:
The effect of bevacizumab, 5-fluorouracil, and triamcinolone on the healing modulation of surgical wounds in rats

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Date
2023
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Authors
Simarro Rios, José Eduardo ; Marques Almeida, Fábio ; Murillo Limongi, Roberto ; Souza Lino-Junior, Ruy de ; Alves de Araújo, Lilhian ; Pereira de Ávila, Marcos ; Magacho, Leopoldo
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-583
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info:eu-repo/semantics/article
Description
Abstract
In this study, we aimed to analyze the effect of 5-fluorouracil, triamcinolone, and bevacizumab on scar modulation in an experimental rat model of surgical lesions. Rats (Rattus norvegicus albinus) were divided into four groups: bevacizumab, 5-fluorouracil + triamcinolone, bevacizumab + 5-fluorouracil + triamcinolone, and control (received no medication) groups. A linear, dorsal incision was created and sutured for the first intention wound healing, mimicking the surgical incision of upper blepharoplasty. Treatments were initiated on day 7, and the rats were euthanized on day 14. Only in the 5-fluorouracil + triamcinolone group was there a difference in the number of infiltrated monocytes. There was 56%, 86%, and 85% decrease in the number of neovessels in the bevacizumab, 5fluorouracil + triamcinolone, and bevacizumab + 5fluorouracil + triamcinolone groups, respectively, compared with the control. Picrosirius red staining showed higher collagen density and more organized collagen in the treatment groups than in the control group. Scar modulation was observed in all groups, but the 5-fluorouracil + triamcinolone group presented the best results. To our knowledge, this is the first study to evaluate the influence of three medications in combination on healing. When used together, these medications can prevent the development of unsightly scars, and are therefore promising alternatives to corticosteroids.
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BVZ , 5-FU , Triamcinolone , Scar , Scarring modulation
Citation
Histology and Histopathology Vol. 38, nº8 (2023)
URI
http://hdl.handle.net/10201/133711
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Histology and histopathology Vol.38, nº8 (2023)
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