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The effect of bevacizumab, 5-fluorouracil, and triamcinolone on the healing modulation of surgical wounds in rats

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dc.contributor.authorSimarro Rios, José Eduardo
dc.contributor.authorMarques Almeida, Fábio
dc.contributor.authorMurillo Limongi, Roberto
dc.contributor.authorSouza Lino-Junior, Ruy de
dc.contributor.authorAlves de Araújo, Lilhian
dc.contributor.authorPereira de Ávila, Marcos
dc.contributor.authorMagacho, Leopoldo
dc.date.accessioned2023-09-07T09:19:25Z
dc.date.available2023-09-07T09:19:25Z
dc.date.issued2023
dc.description.abstractIn this study, we aimed to analyze the effect of 5-fluorouracil, triamcinolone, and bevacizumab on scar modulation in an experimental rat model of surgical lesions. Rats (Rattus norvegicus albinus) were divided into four groups: bevacizumab, 5-fluorouracil + triamcinolone, bevacizumab + 5-fluorouracil + triamcinolone, and control (received no medication) groups. A linear, dorsal incision was created and sutured for the first intention wound healing, mimicking the surgical incision of upper blepharoplasty. Treatments were initiated on day 7, and the rats were euthanized on day 14. Only in the 5-fluorouracil + triamcinolone group was there a difference in the number of infiltrated monocytes. There was 56%, 86%, and 85% decrease in the number of neovessels in the bevacizumab, 5fluorouracil + triamcinolone, and bevacizumab + 5fluorouracil + triamcinolone groups, respectively, compared with the control. Picrosirius red staining showed higher collagen density and more organized collagen in the treatment groups than in the control group. Scar modulation was observed in all groups, but the 5-fluorouracil + triamcinolone group presented the best results. To our knowledge, this is the first study to evaluate the influence of three medications in combination on healing. When used together, these medications can prevent the development of unsightly scars, and are therefore promising alternatives to corticosteroids.es
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dc.format.extent9es
dc.identifier.citationHistology and Histopathology Vol. 38, nº8 (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-583
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/133711
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBVZes
dc.subject5-FUes
dc.subjectTriamcinolonees
dc.subjectScares
dc.subjectScarring modulationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.1 - Patología del sistema circulatorio, de los vasos sanguíneos. Transtornos cardiovasculareses
dc.titleThe effect of bevacizumab, 5-fluorouracil, and triamcinolone on the healing modulation of surgical wounds in ratses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nº8 (2023)