Publication: Modification of swine serum-induced bile duct lesion in BALB/c mice by cyclophosphamide
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Date
1990
Authors
Doi, K. ; Honjo, K. ; Doi, C. ; Mitsuoka, T.
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Effects of cyclophosphamide (CY) on the
antibody titer level and incidence and severity of swine
serum (SS)-induced bile duct lesion (BDL) were
examined. BDL induced by 0.2 m1 of SS per head twice a
week for 2 weeks was characterized by hyperplasia of
biliary epithelial cells, proliferation of mucous glands,
and periductal infiltration of eosinophils with mild
fibrosis. CY showed no significant influence on the
above-mentioned parameters at the dose levels of 140
and 210 mg/kg. On the other hand, CY lowered the
antibody titer level and decreased the seventy of BDL at
the dose level of 280 mg/kg, and it suppressed the
antibody response and BDL at the dose level of 280 X 2
mg/kg. Thus the antibody titer level and the severity of
BDL were closely related each other.
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